In vitro anthelmintic activity,

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Aim: To investigate the cytotoxicity of a fresh ginger extract on some skin tumor cells compared to normal cells. Material and methods: C32 amelanotic melanoma cell line and CCD human skin fibroblasts were used.

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The fresh extract obtained by crushing ginger rhizome was examined for phenolic content. Results: Both concentrations used for treatment induced no changes in normal the morphology and viability of fibroblasts compared to control cells.

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Amelanotic melanoma cells displayed profound changes in cell morphology such as cell shrinkage, rounding up and membrane blebbing and a decrease in cell viability in a dose-dependent manner. Conclusions: Fresh ginger extract induced no changes in normal skin fibroblast viability, but caused profound cytotoxic effects on amelanotic melanoma. These results could encourage further studies regarding the intimate mechanisms of the antitumor action displayed by the fresh ginger extract.

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Fruit, vegetables, and cancer prevention: a review of the epidemiolog-ical evidence. Nutr Cancer ; 18 1 : Benefits of whole ginger extract in prostate cancer.

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Brit J Nutr ; 4 : — Shukla Y, Singh M. Cancer preventive properties of ginger: A brief review. Food Chem Toxicol ; 45 5 : — Development in vitro anthelmintic activity cutaneous amelanotic melanoma in the absence of a functional tyrosinase.

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Pigment Cell Res ; 14 6 : — Antiproliferative effects papilloma seno mascellare essential oils and their major constituents in human renal adenocarcinoma and amelanotic melanoma cells. Cell Prolif ; 41 6 : In vitro screening for anthelmintic and antitumour activity of ethnomedicinal plants from Thailand.

J Ethnopharmacol ; 3 : Antiproliferative activity on human cancer cell lines after treatment with polyphenolic compounds isolated from Iris pseudopumila flowers and rhizomes. Naturforsch C ; 64 : Analysis of total phenols and other oxidation substrates and antioxidants by means of Folin-Ciocalteu reagent, Meth Enzymol ; — Poly-phenol-rich extract from Pinus sylvestris L.

Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays.

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J Immunol Met ; 65 1—2 : 55— Ghasemzadeh A, Jaafar Hawa Z. Antioxidant potential and anticancer activity of young ginger Zingiber officinale Roscoe grown under different CO2 concentration. J Med Plants Res ; 5 14 :

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